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In conclusion, titanium dioxide is a versatile over-the-counter manufacturer with a wide range of applications in various industries. Its unique properties make it an essential ingredient in the formulation of consumer products, providing benefits such as UV protection, whitening, and preservation. As technology continues to advance, the use of titanium dioxide is likely to expand even further, meeting the growing demands of consumers for safe and effective products.

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In a study published in the journal Food and Chemical Toxicology in 2016, researchers investigated whether titanium dioxide exposure led to an increase in colorectal tumor creation in mice by using a colitis associated cancer model. By measuring tumor progression markers, the researchers found that mice given titanium dioxide experienced enhanced tumor formation in the distal colon.  There was also a decrease of cells that act as a protective barrier in the colon. The researchers wrote: “These results suggest that E171 could worsen pre-existent intestinal diseases.”

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